1Coil Day9:15 am, Wednesday, August 28th, 2013140 Cory Hall, Newest Instructiona

1Coil Day9:15 am, Wednesday, August 28th, 2013140 Cory Hall, Newest Instructiona www.phwiki.com

1Coil Day9:15 am, Wednesday, August 28th, 2013140 Cory Hall, Newest Instructiona

Danielson, Emilee, Morning On-Air Personality has reference to this Academic Journal, PHwiki organized this Journal 1Coil Day9:15 am, Wednesday, August 28th, 2013140 Cory Hall, Newest Instructional Lab, EECS Dept.UC Berkeley2What Coil Day Will/Won’t CoverWillWon’tC13 receive arrays as long as small animals at 3 TSample-noise dominance vs. coil-noise dominanceComparisons/contrasts to proton surface coilsProton trapsTuning in addition to matchingC13 preampsQ-spoilingArray DecouplingCables in addition to cable trapsBuilding skills in addition to testing techniques not in the literature Volume coils (body coils)Birdcage coilsDouble-tuned coilsTransmit coils3A Few ReferencesD.I. Hoult in addition to R.E. Richards, The signal-to-noise ratio of the nuclear magnetic resonance experiment, Journal of Magnetic Resonance, Vol. 24, pp. 71-85, 1976.D.I. Hoult, The NMR receiver: A description in addition to analysis of design, Progress in NMR Spectroscopy, Vol. 12, pp. 41-77, 1978.P.B. Roemer, W.A. Edelstein, C.E. Hayes, et al., The NMR phased array, Magnetic Resonance in Medicine, Vol. 16, pp. 192-225, 1990.P.J. Fish, Electronic noise in addition to low noise design, Macmillan, 1993.G. Scott, Build your own receiver coils, personal notes, Stan as long as d University, 1997.J.H. Ardenkjaer-Larsen, B. Fidlund, A.Gram, et al., Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR, Proceedings of the National Academy of Sciences, USA, Vol. 100, pp. 10158-10163, 2003.L. Darasse in addition to J.C. Ginefri, Perspectives with cryogenic RF probes in biomedical MRI, Biochimie, Vol. 85, pp. 915-937, 2003.J. Mispelter, M. Lupu in addition to A. Briguet, NMR probeheads as long as biophysical in addition to biomedical experiments, Imperial College Press, 2006.F.D. Doty, G. Entzminger, J. Kulkarni, K. Pamarthy in addition to J. P. Staab, Radio frequency coil technology as long as small-animal MRI, NMR Biomed., Vol. 20, pp. 304-325, 2007.J-X. Wang, N. Tian, F.J. Robb, A.P. Chen, L. Friesen-Waldner, B.K. Rutt in addition to C.A. McKenzie, An 8-channel coil array as long as small animal 13C MR imaging, ISMRM, 2010.J. Tropp, J.M. Lupo, A. Chen, et al., Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 Tesla on a clinical MR scanner, Journal of Magnetic Resonance, Vol. 208, pp. 171-177, 2011.J.T Vaugh in addition to J.R. Griffiths, eds., RF coils as long as MRI, John Wiley in addition to Sons, 2012.J.P. Dunsmore, H in addition to book of microwave component measurements with advanced VNA techniques, John Wiley in addition to Sons, 2012.B. Keil, Construction of receive arrays, ISMRM, 2013.

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4Revealing Cancer Metabolism w/C13 Imaging Pyruvic acid metabolizes into lactate & alanine differently in tumors, compared to normal tissue:The sign of pyruvate/lactate flips.Figue 4 from M.J. Albers et al., Cancer Research, 2008 (Kurhanewicz Group, UCSF).5Figue 2 from M.J. Albers et al., Cancer Research, 2008 (Kurhanewicz Group, UCSF).6Rat birdcage coil: normal rat injected with hyperpolarized urea . Thiis makes it possible to image the urea filtrate in the kidneys. This has potential use as a non-toxic perfusion measurement (at present, the only alternative involves nuclear medicine scans, but many patients with congenital kidney problem are children, who we wouldn’t want to expose to radiation).Images courtesy Galen Reed, Vigneron Group, UCSF Mission Bay 3 T scannerC13 image (from double-tuned tx-rcv birdcage coil)The colorized C13 image is overlaid on an H1 anatomy image, also acquired w/the birdcage coil.

7C13 imageColorized C13 image overlaid on H1 anatomy imageImages courtesy Galen Reed, Vigneron Group, UCSF Mission Bay 3 T scannerRecent results: tagging hyperpolarized urea with N15 in addition to exploiting long T2 Images courtesy Peter Shin, Vigneron Group, UCSF Mission Bay 3 T scannerAnesthetized rat in two 4-ch C13 paddle coilsTail-vein catheter as long as injection of hyperpolarized pyruvic acid (C13)C13 Parallel ImagingCh 1Ch 2Ch 3Ch 4Ch 5Ch 6Ch 7Ch 8SSoSImages courtesy Peter Shin, Vigneron Group, UCSF Mission Bay 3 T scannerC13 images from each of the 8 coils in the two paddles:Note: these two 4-ch paddle arrays were designed as long as human liver in addition to brain imaging. It would be nice to have smaller, animal-dedicated, phased array coils – as long as better sensitivity.

10Hyperpolarizer (GE Spin Lab)Photos: UCSF Mission BaySmall vial (made out of PEEK plastic) as long as pyruvic acid in addition to /or urea. If both are polarized together, the urea is put in the vial first, then the vial is dunked in liquid nitrogen in addition to frozen, then the pyruvic acid is added on top of the frozen urea. They are frozen separately to prevent mixing.The pyruvic acid is mixed with Trityl, in addition to pipetted into the vial:Then the vial is put in the hyperpolarizer as long as 2 hours (3.35 Tesla, 1.3 oK).11Double-tuned, C13 & H1, birdcage rat coil (tx & rcv as long as C13 & H1)Double-tuned, C13 & H1, birdcage mouse coil (tx & rcv as long as C13 & H1)Photos: UCSF Mission BayAfter the pyruvic acid in addition to /or urea is dissolved in addition to removed from the hyperpolarizer, the spins only stay aligned as long as ~1 minute, so it’s immediately injected into a rat or mouse in addition to imaged.These are two commonly used birdcage coils at UCSF Mission Bay. The rat’s nose sticks out this end in addition to is cupped with this anesthesia hose:12Photos: UCSF Mission BayFor parallel imaging on a human subject, these two 4-channel paddle-shaped C13 receive-only arrays are available. The paddles must be used with a C13 transmitter such as this clamshell-shaped one (in Helmholtz coil configuration):GE designer: Dr. James TroppJ Magn Reson. 2011 January; 208(1): 171-177.

Eight C13 preampsGE 8-channel C13 rat coil (from ISMRM 2010 abstract)Inner cylinder: 8-ch C13 receive array, around the circumference of the cylinderOuter cylinder: Birdcage C13 transmitter13Hard to see in this photo, but we’d like to have a copy of this 8-ch C13 receive array, as it would be useful to a number of UCSF researchers.For parallel imaging acceleration, we like the geometrical configuration of having the 8-channels wrapped around the circumference of a cylinder.Inner cylinder: 8-ch C13 receive array, around the circumference of the cylinder1415For Coil Day, we’re going to build a similar rat 8-ch C13 receive array, along with the associated preamps. For the C13 transmitter, we’ll be using the clamshell tx which already exists at UCSF Mission Bay. Our rat cylinder will go inside the clamshell in addition to both will slide into the bore of the 3 T scanner (where the body coil is used as long as H1 anatomy images of the rat).

1617Sample-noise dominance vs. coil-noise dominance still to do 18Fill factor: metric regarding the geometric coincidence between the coil in addition to the sampleFill factor’s original definition: measure of the fraction of the (solenoildal)coil volume occupied by the sampleFill factor = (Magnetic energy stored inside the sample volume)/(Total magnetic energy stored by the coil) in addition to some more slides still to do

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