A STUDY ON CELL ADHESION BY USING MEMS TECHNOLOGY Rui Qiao Xiaohui Tan ME-381 De
Pinheiro, Jill, Managing Editor has reference to this Academic Journal, PHwiki organized this Journal A STUDY ON CELL ADHESION BY USING MEMS TECHNOLOGY Rui Qiao Xiaohui Tan ME-381 Dec. 5 Presentation Outline Introduction in addition to motivation Current MEMS systems in this area Our idea Conclusion Meaning of this research Underst in addition to the evolution of tissues in addition to organs Manipulate the adhesion http://health.allrefer.com/
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Why MEMS Cells in addition to MEMS are in the similar scale Cells can survive on artificial surfaces The microfabrication technique is relatively mature Some of Current Models Single MEMS sensor A bed of microneedles Model I In-situ adhesion studies of a single living bovine endothelial cell using MEMS sensor The MEMS sensor consists of a cantilever beam made of Single Crystal Silicon (SCS), 1200 µm long x 11.5 µm deep x 4 µm wide, coated by a thin native silicon dioxide layer.
Experimental System Experimental Result The adhesion properties of a single living bovine endothelial cell was studied. Quantitatively it has been found that a focal adhesion site, prior to failure, applies 37 nN of as long as ce onto the MEMS sensor. Focal adhesion Procession of a breaking filopodia
Discussion This work is one of the earliest studies on cell adhesion. The device is quite simple in addition to they can measure the magnitude of the adhesion as long as ce This device doesnt have much control on the contact of the cell in addition to the beam Can only measure the as long as ce as long as m on contact region Model II Cells lying on a bed of microneedles: An approach to isolate mechanical as long as ce Strategy A strategy to independently manipulate mechanical compliance in addition to surface chemistry: as long as small deflections, the deflection is directly proportional to the as long as ce applied by the attached cell
Fabrication Fabrication Contd Result Both the magnitude in addition to direction of the adhesion as long as ces can be obtained
Advantages Less assumptions Can capture the magnitude also the direction of the as long as ce at the same time The mechanical property of the substrate can be easily changed without change the material of the substrate Disadvantage The resolution of this model only in micrometer scale while the focal adhesion is also in this scale Improving the resolution means increasing the density of posts in the array, which leads to a high requirement of deflection measuring precision Our idea Use the membranes to measure the focal adhesion as long as ces. As the de as long as mation is vertical, the dots could be very close without any interactions
MEMS System Fabricate an array of membranes on a silicon wafer. Those membranes will de as long as m under cell adhesion Fabrication process Photolithograph Cast PDMS Electrical etching Microcontact printing Measurement Use optical readout to detect the displacement of each membrane
Discussion Advantage Can improve the spatial resolution Can determine the adhesion as long as ce from each focal contact site. Disadvantage Cannot get the direction of the as long as ce Readout device is complicated Conclusion Introduced two MEMS system already used. Provided a new device, which needs experiment to prove With the size of device decreasing, NEMS system will act important roles in this area ACKNOWLEDGEMENT Professor Horacio D. Espinosa TA: Yong Zhu Team members
Pinheiro, Jill Managing Editor
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