Case report The eleven month old boy was admitted because of mild myocardial hyp

Case report The eleven month old boy was admitted because of mild myocardial hyp www.phwiki.com

Case report The eleven month old boy was admitted because of mild myocardial hyp

Tyda, David, Executive Editor has reference to this Academic Journal, PHwiki organized this Journal Case report The eleven month old boy was admitted because of mild myocardial hypertrophy in addition to persistently elevated blood pressure (140/80 mmHg, > 97 percentile) Family history revealed several cases of essential hypertension Next steps: Is there a primary impact of family history on first diagnostic steps

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Next steps: Is there a primary impact of family history on first diagnostic steps If you assume genetic hypertension how do you proceed Basic investigations Kindey normal Funduscopy no pathology ECG hypertrophy no ECHO size in addition to function normal Duplex-ultrasound kidney no pathology Abdominal ultrasound no vascular abnormality Captopril scintigraphy no pathology Endocrine workup Sodium, potassium normal PRA, serum aldosterone normal Epinephrine, norepinephrine normal Cortisol, ACTH normal 11-desoxycortisol normal DHEA, NPY, testosterone normal

Steroid profile in urine Tetrahydrocortisol + 5 tetrahydrocortisol / tetrahydrocortison Defect of 11-hydroxysteroid dehydrogenase (11 HSD) 11 HSD is the key enzyme in the process of interconversion of cortisol in addition to cortisone Cortisol binding to mineralocorticoid receptor stimulates the receptor Genetic anlaysis of the 11 HSD gene was per as long as med. Genetic analysis Homozygous mutation in exon 2 at codon 161 (Leucine161Glycine) Worldwide only 50 patients with AME described (infant hypertension, low birth weight, hypokaliemic alkalosis, low plasma renin in addition to low aldosterone) Recommended therapy: aldosterone antagonist

Tyda, David Desert Living Magazine Executive Editor www.phwiki.com

Tyda, David Executive Editor

Tyda, David is from United States and they belong to Desert Living Magazine and they are from  Phoenix, United States got related to this Particular Journal. and Tyda, David deal with the subjects like Architecture; Interior Design

Journal Ratings by Vinnica National Technical University

This Particular Journal got reviewed and rated by Vinnica National Technical University and short form of this particular Institution is UA and gave this Journal an Excellent Rating.