Causes of Brain Damage: Cerebrovascular Disorders Cerebrovascular Disorders Cerebral Ischemia Cerebral Ischemia
Brand, Ashley, Meteorologist has reference to this Academic Journal, PHwiki organized this Journal BRAIN DAMAGE AND HUMAN NEUROPSYCHOLOGICAL DISEASES Outline 1. Causes of Brain Damage a. Tumors b. Cerebrovascular Disorders c. Closed-Head Injuries d. Infections e. Neurotoxins 2. Neuropsychological Diseases a. Epilepsy Kindling Model of Epilepsy b. Alzheimers Disease Transgenic Mouse Model of Alzheimers Disease c. Parkinsons Disease MPTP Model of Parkinson’s Disease Causes of Brain Damage: Tumors A tumor (neoplasm) is a group of cells growing independently of the rest of the body a tumor can be Encapsulated (grow within their own membrane) usually benign (can be removed without further risk of growth) Infiltrating (grow diffusely through surrounding tissue) Usually malignant (difficult to remove or destroy in addition to likely to spread) Metastatic tumors are tumors that originate in one organ in addition to spread to another the symptoms of multiple cerebral tumors are often the first signs of lung cancer 20% of brain tumors are meningiomas that grow in the meninges they are encapsulated in addition to benign
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Cerebrovascular Disorders Stroke” is commonly used to refer to any cerebrovascular disorder of sudden onset Two types 1) cerebral hemorrhage the bursting of aneurysms (balloon-like dilations of weak areas of blood vessels) is a major cause of intracerebral bleeding aneurysms can be congenital or the result of infection, toxins etc. Cerebrovascular Disorders 2) Cerebral ischemia is a disruption of blood supply to an area of the brain Three main causes (1) in thrombosis a plug (a thrombus) becomes lodged at its site of as long as mation the plug may be due to a blood clot, fat, cancerous cells, etc. (2) in embolism a plug (an embolus) travels from its site of as long as mation in addition to becomes lodged in a smaller blood vessel (3) in arteriosclerosis the blood vessel walls thicken in addition to the space inside narrow usually from the accumulation of fat
Cerebral Ischemia The brain damage caused during an ischemic episode is believed to be due to an excessive release of excitatory amino acids Glutamate, the brains most prevalent excitatory amino acid neurotransmitter, is released in excessive quantities when blood vessels are blocked Cerebral Ischemia The excessive glutamate over-activates glutamate receptors on postsynaptic membrane sites NMDA (N-methyl-D-aspartate) receptors Thus, too many Na+ in addition to Ca++ ions are allowed to enter the postsynaptic neuron The over abundance of Na+ in addition to Ca++ triggers (a) an excessive release of glutamate, causing a cascade of this toxic effect (b) triggers a sequence of reactions that kills the postsynaptic neuron They are excited to death
Cerebral Ischemia The brain damage caused by ischemia takes a while to develop (days) Does not occur equally in all regions of the brain Hippocampus is particularly vulnerable Researchers are currently studying the ability of NMDA receptor blockers administered directly after a stroke to reduce subsequent brain damage Closed-Head Injuries A brain contusion is an injury in which there is bleeding from the brain in the absence of a laceration the bleeding results in a hematoma (a bruise or collection of clotted blood) contusions are caused by the brain hitting the skull, in addition to they are often contre coup (on other side of brain from blow) Concussion is the diagnosis when a blow to the head disrupts consciousness, but no evidence of physical damage can be found the punch-drunk syndrome is general dementia due to an accumulation of many concussions The case of Jerry Quarry Infections Encephalitis is the general term as long as inflammation of the brain resulting from infection Bacterial infections can be treated with antibiotics, but if left untreated they can cause meningitis (inflammation of meninges) brain abscesses (pockets of pus), general paresis (a syndrome of weakness in addition to dementia) Syphilis passed through contact with genital sores Can remain dormant as long as several years, then turn virulent in addition to attack many parts of the body, including the brain General paresis
Infections Viral infections include infections that preferentially attack the nervous system (e.g., rabies virus) infections that show no preference as long as the nervous system but still sometimes attack it (e.g., mumps in addition to herpes viruses) Viruses may play a key role in the etiology of many neuropsychological disorders Their role is often hard to study because they may lie dormant not produce symptoms until years after they invade the nervous system Neurotoxins Brain damage can be produced by a variety of toxins in the environment “mad hatters” were the result of mercury poisoning Mercury in the felt “crackpots” were originally those who drank tea from cracked ceramic pots with lead cores Sometimes drugs used to treat a disease can have neurotoxic effects Tardive dyskinesia is a disorder produced by prolonged exposure to certain antipsychotic medications
Questions as long as Film What are symptoms of Parkinsons Disease What happens in the brain that produces Parkinsons disease What causes Parkinsons disease What was the initial treatment as long as Parkinsons disease that was discussed in the film. L-Dopa what is it What was the problem with this treatment Where did the Mexican surgeons get the cells they implanted in the Parkinsons patients Where did the Swedish surgeons get the cells they implanted in the Parkinsons patients Where did the Swedish surgeons implant the stem cells in the MPTP patients brains Caudate in addition to Putamen Why there in addition to not the Substantia Nigra Why did the procedure work better as long as MPTP patients than as long as traditional Parkinsons patients What was one of the big advantages of discovering the MPTP molecule Animal models deprenyl monoamine agonist = MAO inhibitor Why was it that the Swedes did not use Connie as a subject at first.
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