Controlled Drug Delivery: PURDUE Plastics

Controlled Drug Delivery: PURDUE Plastics www.phwiki.com

Controlled Drug Delivery: PURDUE Plastics

Mairs, Gary, Contributing Writer has reference to this Academic Journal, PHwiki organized this Journal Controlled Drug Delivery: From Macro as long as mulation to Nanotechnology PURDUE UNIVERSITY Pharmaceutics & Biomedical Engineering Purdue Cancer Center Kinam Park Modern medicine would not exist without drugs Reasons as long as the high cost of drug development New Chemical Entities: 1/4~1/3 are unusable due to unfavorable physicochemical & biochemical properties

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“One word. Just one word: Plastics. There’s a great future in plastics.” Plastics EVOLUTION OF DRUG DELIVERY SYSTEMS Patience Compliance & Convenience Enhancement of Products Extension of product life (or patent life) Delivery of Drugs with Unfavorable Properties Synergistic partnership with drug discovery

Patience Compliance & Convenience Enhancement of Products Once-a-day Once-a-week Once-a-month Once-a-year Once-a-decade On-dem in addition to Norplant: Made of Silicone rubber 36 mg levonogestrel. 85 ug/day (later 30 ug/day) up to 7 years. Macro as long as mulations EVOLUTION OF DRUG DELIVERY SYSTEMS Patience Compliance & Convenience Enhancement of Products Extension of product life (or patent life) Delivery of Drugs with Unfavorable Properties -Poor water solubility -Poor permeability -Poor stability

Transdermal Patches with Microneedles

Nano Drug Delivery Systems Drug Nanoparticles Polymeric drug Polymer-protein conjugate Polyplex: Polymer-DNA complex Polymer-drug conjugate Polymeric micelle Ruth Duncan: The Dawning Era of Polymeric Therapeutics, Nature Reviews 2:347, 2003 Polymeric Nanostructures as long as Drug Delivery

Ideal Drug Delivery Systems 1. High drug loading 2. Drug stability 3. Targeting Long circulation, targeting moiety 4. Cellular absorption Mechanisms 5. Escape from endosome Targeting Cellular Uptake Tumour Targeting Ruth Duncan EPR Effect Antibody Targeting Magnetic field

Folate mediated polymeric micelles Figure. Confocal microscopic images of KB cells incubated with (A, B) DOX micelles in addition to (C, D) DOX/FOL micelles in the presence in addition to absence of folate in the medium. Folate PEG (Mw:3,400) PLGA (Mw:8,000) 104.9 11.5 nm Ref.: Journal of Controlled Release (2004) 96, 273-283 Nanotechnology in Drug Delivery Fabrication of nanodevices: Biodegradable Polymers, Hydrogels) Targeting: Homing moiety (EPR, Ab, GPS) Cellular Uptake: Biological, Mechanical Removal from the body: Biodegradable nanodevices

Mairs, Gary Culturevulture.net Contributing Writer www.phwiki.com

Mairs, Gary Contributing Writer

Mairs, Gary is from United States and they belong to Culturevulture.net and they are from  San Francisco, United States got related to this Particular Journal. and Mairs, Gary deal with the subjects like Motion Pictures; Performing Arts; Theater

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This Particular Journal got reviewed and rated by Valley Forge Christian College and short form of this particular Institution is PA and gave this Journal an Excellent Rating.