Early Brain Changes of Non-Amyloid Pathways Acknowledgements Outline Cross-sectional in addition to Longitudinal Memory Per as long as mance Clinical Consequences

Early Brain Changes of Non-Amyloid Pathways Acknowledgements Outline Cross-sectional in addition to Longitudinal Memory Per as long as mance Clinical Consequences www.phwiki.com

Early Brain Changes of Non-Amyloid Pathways Acknowledgements Outline Cross-sectional in addition to Longitudinal Memory Per as long as mance Clinical Consequences

Michaels, Rosemary, News Director has reference to this Academic Journal, PHwiki organized this Journal Early Brain Changes of Non-Amyloid Pathways Charles DeCarli, MD Victor in addition to Genevieve Orsi Chair in Alzheimer’s Research Director University of Cali as long as nia at Davis, Alzheimer’s Disease Center Acknowledgements Funded in part by Grant R13 AG030995 from the National Institute on Aging The views expressed in written conference materials or publications in addition to by speakers in addition to moderators do not necessarily reflect the official policies of the Department of Health in addition to Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. Outline Brain Aging: cognition in addition to structural imaging Potential Causes of heterogeneity Amyloidosis (brief) Vascular risk factors Time course of vascular risk on brain Inflammation in addition to brain aging

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Cross-sectional in addition to Longitudinal Memory Per as long as mance Clinical Consequences Mungas, et al. Psychology in addition to Aging, 2010 MRI Measures of Atrophy

Variability in Brain Aging Summary Brain aging is heterogeneous Cognition Brain structure Outline Brain Aging: cognition in addition to structural imaging Potential Causes of heterogeneity Amyloidosis (brief) Vascular risk factors Time course of vascular risk on brain Inflammation in addition to brain aging

Percent PiB+ with Age Morris et al, Annals of Neuro, 2010 Time Dependent Differences Jack, et al. JAMA Neurology, 2015 Framingham Heart Study, unpublished data

Prevalence of Vascular Risk Factors among the Framingham Offspring DeCarli, et al. Neurobiology of Aging, 2005 Seshadri, S. et al. Stroke 2006;37:345-350 Future Risk of Stroke or Dementia at Age 65 Women Men Spectrum of CVD MRI Infarction Stroke White Matter Hyperintensities Brain Atrophy

MRI Examples of WMH in addition to SBI Normal WMH Extensive WMH Silent MRI Infarct Debette et al, Stroke, 2010 Age-Specific Prevalence of SBI DeCarli, et al. Neurobiology of Aging, 2005

Aging White Matter Disease 0.30 0.29 0.25 0.23 0.20 Vascular Risk DeCarli, et al. Neurobiology of Aging, 2005 Quantification of age-related differences in WMH Define Large WMH as 1 sd above age-related mean WMH Vascular Risk in addition to WMH

Risk Factors, Age in addition to Brain Volume Cognitive Consequences

Michaels, Rosemary KFLG-AM News Director www.phwiki.com

Middle Life Vascular Risk Factors in addition to Dementia Risk Whitmer, et al, Neurology, 2005 Increasing odds of Dementia with number of Risk Factors Whitmer, et al, Neurology, 2005 ~74% Caucasian

Dementia Risk with MRI Vascular Measures Debette et al, Stroke, 2010 0 VR 1 VR 2 VR 3 VR Significant change in FA Significant negative Jacobians Both Impact of Vascular Risk (VR) on White Matter Integrity in addition to Gray Matter Atrophy Maillard et al, Neurobiology of Aging, 2015 Significant FA loss /year Significant Atrophy /year Number of VR

IDeA Lab Owen Carmichael Evan Fletcher Baljeet Singh Noel Smith Alex in addition to ra Roach Samuel Lockhart Jing He Pauline Maillard Supported by NIH in addition to the Dana Foundation http://neuroscience.ucdavis.edu/idealab/

Michaels, Rosemary News Director

Michaels, Rosemary is from United States and they belong to KFLG-AM and they are from  Bullhead City, United States got related to this Particular Journal. and Michaels, Rosemary deal with the subjects like International News; Local News; National News; Regional News

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