He Lab Overview: Overview VIOLIN: Vaccine Investigation in addition to Online In as long as mation Network – http://www.violinet.org Vaxign: Vaccine Design -the 1st web-based vaccine design system based on reverse vaccinology http://www.violinet.org/vaxign VO-based literature mining

He Lab Overview: Overview VIOLIN: Vaccine Investigation in addition to Online In as long as mation Network - http://www.violinet.org Vaxign: Vaccine Design -the 1st web-based vaccine design system based on reverse vaccinology http://www.violinet.org/vaxign VO-based literature mining www.phwiki.com

He Lab Overview: Overview VIOLIN: Vaccine Investigation in addition to Online In as long as mation Network – http://www.violinet.org Vaxign: Vaccine Design -the 1st web-based vaccine design system based on reverse vaccinology http://www.violinet.org/vaxign VO-based literature mining

Michaels, Alan, Host has reference to this Academic Journal, PHwiki organized this Journal He Lab Overview: Systems Biology Studies of Host-pathogen Interactions in addition to Vaccines (Workshop on Data, Text, Web & Social Network Mining) Yongqun “Oliver” He Unit as long as Laboratory Animal Medicine Department of Microbiology in addition to Immunology Center as long as Computational Medicine in addition to Bioin as long as matics University of Michigan Medical School Ann Arbor, MI 48109 Overview Brucella in addition to Brucellosis Brucella: intracellular bacterium that causes most common zoonotic brucellosis in humans in addition to animal Lab focuses: Brucella pathogenesis & vaccine Lab goal: Develop a human Brucella vaccine. Brucella vaccine-infected macrophages from wild type mice Brucella vaccine-infected macrophages from Caspase-2 knockout mice Light microscopy Annexin V-PI fluorescence Caspase-2 mediated cell death of macrophages induced by Brucella vaccines but not by virulent Brucella strains

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miniTUBA: dynamic Bayesian network (BN) analysis system – http://www.minituba.org/ Experimentally Confirmed: Casp2, Tnf, Nf-kb, Casp1 Predicted network of Brucella-induced macrophage cell death miniTUBA: A pipeline – – data input, missing data prediction, dynamic BN calculation, – prediction of future event, – output visualization BN+1: Bayesian network expansion – Iteratively test all possible genes Confirmed BN+1 identified new ROS in addition to biofilm regulators (PMID: ) BN+1: find pathway hidden factors Limix: Literature mining & curation system – http://www.limix.org Limix allows us to manually curate a large amount of high quality data in a short period of time. Support: literature search; data input, edition in addition to submisison; data review be as long as e publication; versioning

PHIDIAS: Pathogen-Host Interaction Data Integration in addition to Analysis System – http://www.phidias.us/ Focus: PHI – Pathogen-host interaction Statistics: ~60 pathogens, >700 genomes Model organism: Brucella VIOLIN: Vaccine Investigation in addition to Online In as long as mation Network – http://www.violinet.org Overall goal: A vaccine research database & vaccine data analysis system Manually curated 454 vaccines from 73 pathogens Many programs, e.g., Vaxign (Vaccine Design) in addition to VO (Vaccine Ontology) VIOLIN web cover page Vaxign: Vaccine Design -the 1st web-based vaccine design system based on reverse vaccinology http://www.violinet.org/vaxign Reverse vaccinology: predict vaccine targets first from bioin as long as matics analysis of genomes Applications: UPEC, Brucella, Francisella,

VO: Vaccine Ontology – a community ef as long as t Vaccine Ontology (VO): Controlled vocabulary of terms in addition to relations (“ontology”) in the vaccine domain Allow computers to underst in addition to in addition to analyze data Support computer-assisted reasoning http://www.violinet.org/vaccineontology VO-based literature mining VO-based SciMiner: to index vaccine literature based on VO terms. Joint work with Junguk Hur, Eva Feldman VO-based literature discover of IFNG interaction networks Joint work with Arzucan Özgür, Dragomir R. Radev Acknowledgements Funding: NIH-NIAID, GLRCE, NCIBI University of Michigan He Laboratory / U of Michigan (UM) UM Collaborators: Peter Woolf Brian Athey Harry Mobley Arzucan Özgür, Dragomir R. Radev Junguk Hur, Eva Feldman Dongjuan Dai, Chuanwu Xi Dr. Fang Chen Andrew Hodges Zuoshuang “Allen” Xiang Not in picture: – Sirarat Sarntivijai – Keerthi S. Sannareddy Vaccine Ontology Collaborators: Barry Smith (Buffalo) Lindsay Cowell (Duke) Bjoern Peters (La Jolla Institute) Alan Ruttenberg (Sci. Commons) Ryan Brinkman (BC, Canada) Melanie Courtot (BC, Canada)

Michaels, Alan Alan Michaels In The Morning - KWFM-AM Host www.phwiki.com

Michaels, Alan Host

Michaels, Alan is from United States and they belong to Alan Michaels In The Morning – KWFM-AM and they are from  Tucson, United States got related to this Particular Journal. and Michaels, Alan deal with the subjects like Entertainment; Music

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