Immune system – introduction Eradication of variola (smallpox) ‘Know The Enemy’ The Enemy The Defence

Immune system - introduction Eradication of variola (smallpox) ‘Know The Enemy’ The Enemy The Defence www.phwiki.com

Immune system – introduction Eradication of variola (smallpox) ‘Know The Enemy’ The Enemy The Defence

Burgess, Christina, Operations Manager;Public Service/Community Affairs Director has reference to this Academic Journal, PHwiki organized this Journal Immune system – introduction Radek Spisek Institute of Immunology, 2nd Medical School, Charles University Edward JENNER 1749-1823 Eradication of variola (smallpox)

Lambuth University US www.phwiki.com

This Particular University is Related to this Particular Journal

‘Know The Enemy’ The immune system exists to prevent in addition to combat infection Everything else is secondary to this primary objective Autoimmunity Allergy Tumour immunology Transplantation The Enemy Fungi C in addition to ida Antigens exo – antigens: microbes, as long as eign substances (alo, xeno-grafts, vaccines, sera, drugs – haptens auto-antigens: self tissue Chemical structure: proteins, glykoproteins, mucoproteins, polysacharides, lipids, glykolipids, fosfolipids Membrane receptors, enzymes, nuclear structures, secerned products (bacterial toxines)

Components of the immune system Hematopoetic system Hematopoetic stem cell- CD34 SCT- stem cell transplantation

The Defence Non Specific barriers Anatomical/Physiological Acute phase reactants in addition to Inflammation Complement/Interferons/CRP Innate cells PMN/Macrophages/NK cells Adaptive immunity B cells – Antibody T cells – Orchestration, Cytokines, Lytic granules Innate Defence Adaptive Defence Why Differentiate between the Innate in addition to Acquired Immunity Innate Immunity Characteristics: Universal Rapid Lacks memory Non specific but Acquired Immunity Characteristics: Not universal ‘Slow’ to develop Possesses memory Specific but . ‘Plays to the tune of the Innate immune system’ Innate Immunity Mechanical barriers Inhibit attachment in addition to penetration of microorganisms Intact skin Mucus Cilia Saliva,tears, urine as long as expelling microbes Coughing, sneezing in addition to shedding! Chemical barriers HCL Lysozyme pH

Innate Immunity Inflammation Proteolytic cascades Phagocytosis Cytokines Natural Killer cells

2. ANTIGEN NONSPECIFIC MECHANISMS; PHAGOCYTES, GRANULOCYTES

PHAGOCYTOSIS

ESSENTIAL LINK BETWEEN THE INNATE AND ADAPTIVE SYSTEMS: DENDRITIC CELLS DENDRITIC CELLS MUST BE PRE-STIMULATED BY DANGER SIGNALS TO BE ABLE TO ACTIVATE T LYMPHOCYTES

Burgess, Christina KSWG-FM Operations Manager;Public Service/Community Affairs Director www.phwiki.com

DANGER SIGNALS: – EXOGENOUS (PAMPs) – ENDOGENOUS (e.g. STRESS PROTEINS RELEASED FROM NECROTIC CELLS) TOLL-LIKE RECEPTORS

Adaptive Immunity Effector cells APCs Lymphoid Tissues Primary (Central) Lymphoid organs Secondary (Peripheral) Lymphoid organs Thymus Bone Marrow Spleen Lymph nodes MALT GALT

Transplantation immunity alo-transplantace xeno-transplantace donor recipient rejection Graft versus host

Burgess, Christina Operations Manager;Public Service/Community Affairs Director

Burgess, Christina is from United States and they belong to KSWG-FM and they are from  Wickenburg, United States got related to this Particular Journal. and Burgess, Christina deal with the subjects like Music Programming; Public Service Announcements

Journal Ratings by Lambuth University

This Particular Journal got reviewed and rated by Lambuth University and short form of this particular Institution is US and gave this Journal an Excellent Rating.