Lecture 37 Gene regulation: Control of gene expression. (Prokaryotic cells) Gene
Holifield, Lisa, News Director has reference to this Academic Journal, PHwiki organized this Journal Lecture 37 Gene regulation: Control of gene expression. (Prokaryotic cells) Gene regulation in prokaryotes: 1. By positive control a. with induction of gene expression b. with repression of gene expression 2. By negative control a. with induction of gene expression b. with repression of gene expression. P O A B C R active regulator inactive regulator Structural genes E1 E2 E3 Function DNA RNA protein (Prokaryotic) Operon.
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P O Z Y A R inactive repressor active repressor Function Tryptophan operon: Tryptophan P O Z Y A R Structural genes inactive repressor Without tryptophan: With tryptophan: polymerase P O Z Y A R active repressor inactive repressor Function Lactose operon: Lactose P O Z Y A R Structural genes active repressor Without lactose: With lactose: polymerase
Glucose low, cAMP high promotor activated Glucose high, cAMP low, promotor not activated Glucose: low Lactose: not present Glucose: low Lactose: present
Fig. 14-6, p. 312 Lecture 38 Gene regulation: Eukaryotic cells, Transcription factors.
Regulation of gene expression multicellular organisms: Eukaryotic Gene structure:
Regulation of gene transcription: activation of a TF by phosphorylation.
Regulation of gene transcription: activation of a TF by removal of inhibitor. Eu-chromatin in addition to Hetero-chromatin:
Fig. 10-2a, p. 213 DNA wound around a cluster of histone molecules Histone tails Linker DNA Nucleosome (10 nm diameter) The End.
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