Pharmacodynamic Interactions Pharmacokinetic Interactions Drugs with zero order kinetics Drugs with low bioavailability due to high pre-systemic metabolism (First pass effect Interaction in the gut

Pharmacodynamic Interactions Pharmacokinetic Interactions Drugs with zero order kinetics Drugs with low bioavailability due to high pre-systemic metabolism (First pass effect Interaction in the gut www.phwiki.com

Pharmacodynamic Interactions Pharmacokinetic Interactions Drugs with zero order kinetics Drugs with low bioavailability due to high pre-systemic metabolism (First pass effect Interaction in the gut

Finnerty, Megan, Nightlife Reporter has reference to this Academic Journal, PHwiki organized this Journal Mechanisms of Drug Interaction Pharmacokinetic Reduced rate in addition to /or completeness of absorption Altered bioavailabilty Reduced plasma protein binding Altered tissue distribution Altered hepatic metabolism Altered renal excretion Haemodynamic interactions Pharmacodynamic Potentiation/antagonism at target receptor Potentiation at non-target receptor Alteration of fluid/electrolyte environment Interference with transport mechanisms Pharmacodynamic Interactions Decreased effectiveness Increased toxicity Predictable within a class of drugs Pharmacokinetic Interactions Outcome direct effect of change in drug level Chance of interaction occurring difficult to predict Nature of interaction can be predicted

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Drugs with zero order kinetics

Drugs with low bioavailability due to high pre-systemic metabolism (First pass effect

Interaction in the gut

Interaction in the liver

Finnerty, Megan Arizona Republic Nightlife Reporter www.phwiki.com

Haemodynamic drug interaction

Things to Remember Interactions are easily as long as gotten when prescribing Interactions are difficult to remember Pharmacodynamic interactions can often be predicted across drug classes Pharmacokinetic interactions can not be predicted – experiments needed Many interactions probably remain undescribed – so look out as long as them The chances of interaction are 60 times higher in a patient taking 5 drugs than in one taking 2.

Finnerty, Megan Nightlife Reporter

Finnerty, Megan is from United States and they belong to Arizona Republic and they are from  Phoenix, United States got related to this Particular Journal. and Finnerty, Megan deal with the subjects like Celebrations and Parties; Entertainment; Fashion and Wearing Apparel; Nightlife

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