Results Conclusion References Evaluation of the Effectiveness of Analytical Anisotropic Algorithm in Flattened in addition to Flattening-Filter-Free Beams as long as High Energy Dose Delivery Using the Radiological Physics Center Lung Phantom

Results Conclusion References Evaluation of the Effectiveness of Analytical Anisotropic Algorithm in Flattened in addition to Flattening-Filter-Free Beams as long as High Energy Dose Delivery Using the Radiological Physics Center Lung Phantom www.phwiki.com

Results Conclusion References Evaluation of the Effectiveness of Analytical Anisotropic Algorithm in Flattened in addition to Flattening-Filter-Free Beams as long as High Energy Dose Delivery Using the Radiological Physics Center Lung Phantom

Seward, Bill, Fill-in Sports Anchor has reference to this Academic Journal, PHwiki organized this Journal Results The measured-to-predicted dose ratio criteria used by the RPC to credential institutions is 0.92-1.02, however as long as this work, a criteria of 0.95-1.05 was used to compare the measured results with the calculated doses. In addition, the gamma index analysis criteria as long as this work was set to be ±5%/3mm with 90% of the average number of pixels passing this criteria. All of the target measured-to-predicted dose ratios fell within the ±5% criterion. In addition, all of the gamma analyses also met the 90% criterion even as long as the highest energies. RPC Gamma index using 5%/5mm around 0.97 Care should be taken when considering the RPC limits as long as energies higher than 12 MV, since the original RPC criteria was established based on the statistical analysis of the large number of irradiations in 6-12 MV range, its validity has not been verified as long as energies greater than 12 MV. There was a divergence in the measured profiles from the calculated outside the PTV in superior-inferior direction as long as all plans in addition to beam energies. This deviation represents an increased dose to the tissues outside the planned treatment volume that leads to a higher dose to a normal lung (by 4-5% of the prescribed dose on average) than what was predicted by AAA calculation in the Eclipse TPS. Fig. 2 Deviation of measured dose profiles from the calculated in superior-inferior direction Conclusion The results from both flattened in addition to flatted-filter-free plans in 6-10 MV range are in a good agreement with the RPC data in addition to show that AAA algorithm is capable of calculating treatment plans in a complex heterogeneous environment consistently in addition to accurately using ±5%/3mm gamma index in addition to ±5% point dose criteria. This AGREES with the existing recommendations of only using photon beams energies of 12 MV as long as lung treatments. However, regarding the use of higher photon energies as long as lung treatments, neither 15 MV or 18 MV are recommended to be used in radiation therapy treatments of lung tumors due to a larger penumbra (Wang et al) in addition to potential underdose of the tumor (Klein et al) which can significantly compromise the effectiveness of the radiation treatment in addition to local tumor control. The results from 15 MV in addition to 18 MV plans calculated using AAA delivered to the RPC anthropomorphic lung phantom do not show a decreased dose to the tumor in addition to demonstrate a good agreement between the calculated in addition to delivered doses despite an increased electronic lateral disequilibrium in addition to a larger penumbra as long as higher energies. Our evaluation of the AAA heterogeneity corrected dose calculations using the RPC lung phantom DISAGREES with the recommendation to only use 12 MV as long as lung treatments, specifically as long as the AAA algorithm. References 1) L. Wang, E. Yorke, G. Desobry, in addition to C. Chui, Dosimetric advantage of using 6 MV over 15 MV photons in con as long as mal therapy of lung cancer: Monte Carlo studies in patient geometries, Journal of Applied Clinical Medical Physics 3 (1), 51-59 (2002) 2) E. Klein, A. Morrison, J. Purdy, M. Graham, in addition to J. Matthews, ‘‘A volumetric study of measurements in addition to calculations of lung density corrections as long as 6 in addition to 18 MV photons’’, Int. J. Radiat. Oncol., Biol., Phys. 37, 1163–1170 (1997) Evaluation of the Effectiveness of Analytical Anisotropic Algorithm in Flattened in addition to Flattening-Filter-Free Beams as long as High Energy Dose Delivery Using the Radiological Physics Center Lung Phantom R Repchak1, A Molineu1, R Popple3, S Kry1, R Howell1, D Followill1 (1) MD Anderson Cancer Center, Houston, TX, (2) University of Alabama at Birmingham, Birmingham, AL, Dosimetry Four TLD capsules (two in the target, one in spine, in addition to one in heart) in addition to three orthogonal Radiochromic EBT2 films in axial, coronal, in addition to sagittal planes were used to verify the accuracy of the dose delivered during each phantom irradiation Treatment Planning The CTV was equal to GTV in addition to the PTV was created by exp in addition to ing the CTV by 0.5 cm axially in addition to by 1 cm in superior-inferior direction AAA v.8.9.08 heterogeneity correction was applied as long as volume dose calculations in all plans A single fraction of 6 Gy was prescribed in addition to normalized to at least 95% of the PTV Normal Tissues Constraints A total of six phantom irradiation plans were developed: Two SBRT plans (6 MV in addition to 18 MV) were delivered on the Varian Clinac 2100CD in addition to 21EX linear accelerators Four SBRT plans (6 MV, 6 MV FFF, 10 MV FFF, in addition to 15 MV) were delivered on a Varian TrueBeam STx linear accelerator The analysis of the data was per as long as med in a Computational Environment as long as Radiotherapy Research (CERR) v.3.3 using software developed specifically as long as the RPC Fig. 1 The RPC Lung phantom: Fully assembled phantom (top left); Phantom tumor, heart, in addition to spine inserts (top right); Axial slice of the phantom CT scan (bottom left); Beam arrangements used as long as planning in Eclipse TPS (bottom right). Fig. 3 Change in measured-to-predicted dose ratio with the beam energy Fig. 4 Summary as long as all plans: Measured-to-predicted dose ratios (top); 2D Gamma index results using ±5%/3mm criteria (bottom) This investigation was supported by PHS grants CA10953 in addition to CA81647 awarded by the NCI, DHHS. Title of the Poster Presentation Goes Here Authors of the Poster Presentation Goes Here Institutional in addition to /or Graduate School of Biomedical Sciences Affiliation Goes Here

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