UNC Contributions Shape Analysis Shape Analysis: Methods DTI: Quantitative Analysis DTI Tensor Variability Studies

UNC Contributions Shape Analysis Shape Analysis: Methods DTI: Quantitative Analysis DTI Tensor Variability Studies www.phwiki.com

UNC Contributions Shape Analysis Shape Analysis: Methods DTI: Quantitative Analysis DTI Tensor Variability Studies

Lease, Betty, Features Reporter has reference to this Academic Journal, PHwiki organized this Journal UNC Core 1: What did we do as long as NA-MIC in addition to /or what did NA-MIC do as long as us Guido Gerig, Martin Styner, Casey Goodlett, Ipek Oguz, Isabelle Corouge UNC Contributions Method’s Development: Shape Analysis: Set of methods / automatic complex pipelines / statistical analysis DTI Analysis: New modules / whole toolkit as long as tract-based analysis / atlas-based analysis / statistics Close collaboration Core1/Core2 developers Methods driven by clinical partners UNC/Duke in addition to Core3 Key components integrated into NAMIC toolkit Driving biological problems: Morphometric changes in schizophrenia / connectivity changes in SZ / white matter integrity in SZ Training/education Core5: Testing/training at UNC/Duke be as long as e delivering Material as long as DTI education: Physics/Math/Biology/Tools Chapel Hill DTI Workshop Shape Analysis Statistical Shape Analysis General shape analysis framework Shape Analysis in addition to visualization package (3 NAMIC in addition to 6 outside sites) BWH/Harvard Caudate study

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Shape Analysis: Methods Methods 2D CC subdivision Novel shape analysis Hotelling T2 difference FDR based correction MDL curvature based shape correspondence Shape Analysis Pipeline ready as long as clinical studies in addition to used by NAMIC partners Current integration Slicer 3 DTI: Quantitative Analysis Tract-based analysis: FiberViewer: User-operated tract-based analysis Arc-length correspondence Riemannian tensor statistics Tested & applied in clinical studies Journal paper submitted Atlas based population studies:: Diffeomorphic registration Voxel-wise correspondence Riemannian interpol./statistics Currently applied to VA DTI SZ data Regional subdivision analysis (CC) Currently applied to BWH/Harvard data Collaboration UNC, Utah, Harvard-MIT, BWH/Harvard, Dartmouth DTI Tensor Variability Studies Study effect of MR noise on DTI measurements Gradient direction schemes: Orientation invariance of FA Theory & test scans UNC – Utah collaboration ISMRM submission Potentially important as long as training/education in addition to new clinical studies

Software Developments in addition to Deliverables Delivered fully functional integrated packages/pipelines composed of sets of ITK modules (Shape Analysis / DTI) Participation in ef as long as ts as long as st in addition to ardization in addition to interoperability (e.g., fiber bundles, NRRD, shape representation as long as mats) UNC promotes importance of automatic pipelines/ workflows in addition to batch processing: large clinical studies, competitive comparison of tools, dissemination to research community Early adaptation in addition to testing of KWwidgets (KWMeshVisu, NRRD editor) in addition to Slicer3 prototype environment (shape analysis) What did NAMIC do as long as UNC NAMIC amplifies in addition to complements other NIH-funded UNC projects Funding of method/software development at extent difficult to fund under other grant mechanisms To learn about professional, industry-style of programming & program testing in addition to sharing (dashboard, regression testing) NAMIC toolkit: Excellent plat as long as m to integrate, test, apply in addition to competitively compare UNC methods in addition to tools Impact of NAMIC on UNC Neuroimage Analysis Research: Promotes in addition to demonstrates importance of collaborative research between CS in addition to clinical partners in addition to of sharing of tools in addition to data NAMIC tools in addition to st in addition to ards made available in addition to tested by our local in addition to global non-NAMIC partners NAMIC is very attractive project as long as researchers in addition to students: Exposure to multi-site, collaborative research / high visibility / contacts to research labs in addition to industry / joint collaboration with end users UNC NAMIC Papers DTI: Fiber Tract-Oriented Statistics as long as Quantitative Diffusion Tensor MRI Analysis, Isabelle Corouge, P.Thomas Fletcher, Sarang Joshi, Sylvain Gouttard, Guido Gerig, Medical Image Analysis 10 (2006), 786 – 798 Improved Correspondence as long as DTI Population Studies via Unbiased Atlas Building Casey Goodlett, Brad Davis, Remi Jean, John Gilmore, in addition to Guido Gerig, MICCAI Vol. 4191, 2006, pp. 260 – 267 C. Goodlett, I. Corouge, M. Jomier, in addition to G. Gerig, A Quantitative DTI Fiber Tract Analysis Suite, The Insight Journal, vol. ISC/NAMIC/ MICCAI Workshop on Open-Source Software, 2005 Corouge, I., Fletcher, T., Joshi, S., Gilmore J.H., in addition to Gerig, G., Fiber Tract-Oriented Statistics as long as Quantitative Diffusion Tensor MRI Analysis, MICCAI, LNCS, Vol. 3749, 2005, pp. 131 – 138 M. Styner, R. Gimpel Smith, C. Cascio, I. Oguz, M. Jomier: Corpus Callosum Subdivision based on a Probabilistic Model of Inter-hemispheric Connectivity, MICCAI, LNCS, Vol 3750, 2005 pp. 765-772. John H. Gilmore, Weili Lin, Isabella Corouge, Y. Sampath K. Vetsa, J. Keith Smith, Chaeryon Kang, Hongbin Gu, Robert M. Hamer, Jeffrey A. Lieberman, Guido Gerig Early Postnatal Development of Corpus Callosum in addition to Corticospinal White Matter Assessed with Quantitative Tractography, submitted J. Neuroscience Corpus callosum DTI abnormalities in schizophrenia, M. Kubicki, M. Shenton, G.Gerig, M. Styner, in prep. Shape: M. Styner, I. Oguz, S. Xu, D. Pantazis, in addition to G. Gerig. Statistical group differences in anatomical shape analysis using hotelling T2 metric. Proc SPIE Medical Imaging Conference, in print, 2007. Oguz, Ipek, Gerig, Guido, Barre, Sebastien, Styner, Martin, A Quantitative KWMeshVisu: A Mesh Visualization Tool as long as Shape Analysis, 2006, ISC/NA-MIC Workshop on Open Science at MICCAI 2006, Insight Journal T Heimann, I Oguz, I Wolf, M Styner, HP Meinzer, Implementing the Automatic Generation of 3D Statistical Shape Models with ITK, Open Science Workshop at MICCAI 2006, Insight Journal Styner, M. in addition to Oguz, I. in addition to Xu, S. in addition to Brechbuhler, C. in addition to Pantazis, D. in addition to Levitt, J. in addition to Shenton, M. in addition to Gerig, G.:Framework as long as the Statistical Shape Analysis of Brain Structures using SPHARM-PDM, Open Science Workshop at MICCAI 2006, Insight Journal Software Development : Martin Styner, Matthieu Jomier, in addition to Guido Gerig, Closed in addition to open source neuroimage analysis tools in addition to libraries at UNC, in IEEE International Symposium on Biomedical Imaging (ISBI), special sess. Open Source, pp. 702-705, 2006.

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